Trox-1
Calcium channel blocker, Voltage-dependent calcium channel, Analgesic
978-613-9-27688-2
6139276888
56
2012-01-01
29.00 €
eng
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. TROX-1 is a drug which acts as a potent blocker of the Cav2 type calcium channels. It was developed as a potential analgesic after the discovery that the selective Cav2.2 blocker ziconotide is an active analgesic with similar efficacy to strong opioid drugs but comparatively milder side effects. Unlike ziconotide, TROX-1 is not so selective, and also blocks the Cav2.1 and Cav2.3 calcium channel subtypes, but it has the great advantage of being orally active, whereas ziconotide must be administered , by injection into the spinal fluid. In animal studies of TROX-1, analgesic effects were observed with similar efficacy to such as naproxen or diclofenac, and anti-allodynia effects equivalent to pregabalin or duloxetine.
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