Synthesis of novel bulk and nano biological active beta-lactam
978-613-9-93654-0
6139936543
612
2018-11-06
108.90 €
eng
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β-Lactams, being a structural motif in most widely used antibiotics, have occupied a pivotal position in medicinal chemistry for almost a century now. With the microorganisms retaliating the traditional antibiotics via β-lactamase enzymes, the need for novel antibiotics prevails making the synthesis of newer β-lactams ever more important. Besides their use as antibiotics, β-lactams are increasingly being used as synthons for biologically important molecules. β-Lactams have been found to act as cholesterol acyltransferase inhibitors, thrombin inhibitors, human cytomegalovirus protease inhibitors, matrix metalloprotease inhibitors, cysteine protease, and apoptosis inductors.
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Organic chemistry
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